Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Allender S[original query] |
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Engagement and weight loss: Results from the Mobile Health and Diabetes Trial
Muralidharan S , Ranjani H , Mohan Anjana R , Jena S , Tandon N , Gupta Y , Ambekar S , Koppikar V , Jagannathan N , Allender S , Mohan V . Diabetes Technol Ther 2019 21 (9) 507-513 Background: Prevalence of type 2 diabetes (T2D) is increasing worldwide. Identifying and targeting individuals at high risk, is essential for preventing T2D. Several studies point to mobile health initiatives delivered through personal smart devices being a promising approach to diabetes prevention, through weight loss. The aim of the mobile health and diabetes (mDiab) trial was twofold: to achieve 5% weight loss and to look at the association of weight loss with degree of engagement with the mDiab app. Methods: The mDiab randomized control trial was carried out among smartphone users who are at high risk for T2D mellitus in three cities-Chennai, Bengaluru, and New Delhi in India. The intervention was delivered through a mobile phone application along with weekly coach calls for 12 weeks. While individuals in the intervention group individuals received the app, which enabled tracking their weight, physical activity, and diet along with 12 weekly video lessons on T2D prevention and coach calls, the control group received usual care. Results: The intervention group experienced a significant 1 kg weight loss while the control group lost 0.3 kg (P < 0.05). More individuals in the intervention group (n = 139, 15%) met the 5% weight loss target than in the control group (n = 131, 9%). In the intervention group those who viewed the videos experienced greater weight loss (2.4 kg) than those who only attended coach calls (0.9 kg) (P < 0.01). Conclusions: An mHealth intervention helped to achieve moderate weight loss. Future studies should explore the sustainability of this weight loss. |
Burkholderia humptydooensis sp. nov., a New Species Related to Burkholderia thailandensis and the Fifth Member of the Burkholderia pseudomallei Complex.
Tuanyok A , Mayo M , Scholz H , Hall CM , Allender CJ , Kaestli M , Ginther J , Spring-Pearson S , Bollig MC , Stone JK , Settles EW , Busch JD , Sidak-Loftis L , Sahl JW , Thomas A , Kreutzer L , Georgi E , Gee JE , Bowen RA , Ladner JT , Lovett S , Koroleva G , Palacios G , Wagner DM , Currie BJ , Keim P . Appl Environ Microbiol 2016 83 (5) During routine screening for endemic Burkholderia pseudomallei from water wells in northern Australia, Gram-staining-negative bacteria (strains MSMB43T, MSMB121, and MSMB122) with a similar morphology and biochemical pattern to B. pseudomallei and B. thailandensis were co-isolated with B. pseudomallei on Ashdown's selective agar. To determine the exact taxonomic position of these strains and to distinguish them from B. pseudomallei and B. thailandensis, they were subjected to a series of phenotypic and molecular analyses. Biochemical and fatty acid methyl esters analysis was unable to distinguish B. humptydooensis sp. nov. from closely related species. In MALDI-TOF analysis, all isolates grouped together in a cluster separate from other Burkholderia spp. 16S rRNA and recA sequence analysis demonstrated phylogenetic placement for B. humptydooensis sp. nov. in a novel clade within the B. pseudomallei group. MLST analysis of the three isolates in comparison with MLST data from 3,340 B. pseudomallei strains and related taxa revealed a new sequence type (ST318). Genome to genome distance calculations and average nucleotide identity of all isolates to both B. thailandensis and B. pseudomallei, based on whole genome sequences, also confirmed B. humptydooensis sp. nov. as a novel Burkholderia species within the pseudomallei complex. Molecular analyses clearly demonstrate that strains MSMB43T, MSMB121, and MSMB122 belong to a novel Burkholderia species for which the name Burkholderia humptydooensis sp. nov. is proposed with the type strain MSMB43T (=BAA-2767; LMG 29471, CP013380-CP013382). IMPORTANCE: Burkholderia pseudomallei is a soil dwelling bacteria and the causative agent of melioidosis. The genus Burkholderia consists of a diverse group of species with the closest relatives of B. pseudomallei referred to as the B. pseudomallei complex. A proposed novel species, B. humptydooensis sp. nov, was isolated from a bore water sample from the Northern Territory in Australia. B. humptydooensis sp. nov., is phylogenetically distinct from B. pseudomallei and other members of the pseudomallei complex making it the fifth member of this important group of bacteria. |
Burkholderia pseudomallei type G in Western Hemisphere
Gee JE , Allender CJ , Tuanyok A , Elrod MG , Hoffmaster AR . Emerg Infect Dis 2014 20 (4) 661-3 Burkholderia pseudomallei isolates from the Western Hemisphere are difficult to differentiate from those from regions in which melioidosis is traditionally endemic. We used internal transcribed spacer typing to determine that B. pseudomallei isolates from the Western Hemisphere are consistently type G. Knowledge of this relationship might be useful for epidemiologic investigations. |
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